• JEG-3人绒毛膜癌细胞(STR鉴定正确)

    价 格👳🏻‍♂️:¥1800

    期 货:现货(冻存管发2支)

    保藏中心🤵🏿‍♂️:BTCC

    资源编号🧝🏼‍♀️:BTCC-1084

    产地:中国

    套 餐▪️:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameJEG-3
    SynonymsJeg-3; JEG3; Jeg3; jeg3
    AccessionBTCC-1084
    Resource Identification InitiativeTo cite this cell line use: JEG-3 (BTCC-1084)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Characteristics: Established by serial cloning into hamster cheek pouches.
    Doubling time: ~36 hours (CLS=300222); ~24 hours (DSMZ=ACC-463).
    Karyotypic information: Near tetraploid karyotype (PubMed=33096371).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Caution: A TP53 mutation is indicated as being at p.Gln167His (c.501G>T) in PubMed=7819056 but has not been confirmed by CCLE and Cosmic-CLP.
    Derived from site: Metastatic; Fetal brain; UBERON=UBERON_0006237.
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0.01
    Native American0.09
    East Asian, North0.97
    East Asian, South0
    South Asian0.9
    European, North71.88
    European, South26.16
    DiseaseGestational choriocarcinoma (NCIt: C4646)
    Gestational choriocarcinoma (ORDO: Orphanet_99926)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:



    CVCL_9559 (AC1 [Human gestational choriocarcinoma])CVCL_IV65 (JEG-3/A3-1A7)CVCL_6922 (JEG-3/VP16)
    CVCL_7167 (TEC61)

    Originate from same individualCVCL_0044 ! BeWo
    Sex of cellMale
    Age at samplingFetus
    CategoryCancer cell line
    STR profileSource(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DepMap; DSMZ; KCLB; PubMed=33810901

    Markers:
    AmelogeninX,Y
    CSF1PO11,12
    D1S165614,16
    D2S44114,15
    D2S133824
    D3S135815 (CLS)
    15,16 (CCRID; DepMap; DSMZ; KCLB; PubMed=33810901)
    D5S81810,11
    D7S82010,12
    D8S117912
    D10S124813,15
    D12S39117,24
    D13S3179,11
    D16S53913,14
    D18S5114
    D19S43313,15
    D21S1130
    D22S104515
    FGA23,24
    Penta D9,12
    Penta E8,12
    SE3315,25.2
    TH019,9.3
    TPOX8
    vWA16

    Run an STR similarity search on this cell line
    Web pageshttps://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/j/cell-lines-detail-251.html
    Publications

    PubMed=5103722; DOI=10.1210/jcem-32-5-683
    Kohler P.O., Bridson W.E.
    Isolation of hormone-producing clonal lines of human choriocarcinoma.
    J. Clin. Endocrinol. Metab. 32:683-687(1971)

    PubMed=62839; DOI=10.1093/jnci/56.5.911
    Lieblich J.M., Weintraub B.D., Krauth G.H., Kohler P.O., Rabson A.S., Rosen S.W.
    Ectopic and eutopic secretion of chorionic gonadotropin and its subunits in vitro: comparison of clonal strains from carcinomas of lung and placenta.
    J. Natl. Cancer Inst. 56:911-917(1976)

    PubMed=327080; DOI=10.1093/jnci/59.1.221
    Fogh J., Fogh J.M., Orfeo T.
    One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
    J. Natl. Cancer Inst. 59:221-226(1977)

    PubMed=833871; DOI=10.1093/jnci/58.2.209
    Fogh J., Wright W.C., Loveless J.D.
    Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
    J. Natl. Cancer Inst. 58:209-214(1977)

    PubMed=7459858
    Rousset M., Zweibaum A., Fogh J.
    Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
    Cancer Res. 41:1165-1170(1981)

    PubMed=6220172
    Dracopoli N.C., Fogh J.
    Polymorphic enzyme analysis of cultured human tumor cell lines.
    J. Natl. Cancer Inst. 70:469-476(1983)

    PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3
    Yamashita K., Nakamura T., Shimizu T., Katagiri M., Ikeda H.
    Expression of HLA class I and class II antigens in human choriocarcinoma cell lines.
    Int. J. Gynecol. Obstet. 24:301-307(1986)

    PubMed=3518877; DOI=10.3109/07357908609038260
    Fogh J.
    Human tumor lines for cancer research.
    Cancer Invest. 4:157-184(1986)

    PubMed=7937597; DOI=10.1016/0143-4004(94)90008-6
    Grummer R., Hohn H.-P., Mareel M.M., Denker H.-W.
    Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system.
    Placenta 15:411-429(1994)

    PubMed=7753552
    Brown A.D., Lopez-Terrada D.H., Denny C., Lee K.A.W.
    Promoters containing ATF-binding sites are de-regulated in cells that express the EWS/ATF1 oncogene.
    Oncogene 10:1749-1756(1995)

    PubMed=7819056; DOI=10.1038/bjc.1995.3
    Yaginuma Y., Yamashita T., Takuma N., Katayama H., Ishikawa M.
    Analysis of the p53 gene in human choriocarcinoma cell lines.
    Br. J. Cancer 71:9-12(1995)

    DOI=10.1007/0-306-46861-1_8
    Ganapathy V., Prasad P.D., Leibach F.H.
    Choriocarcinoma.
    (In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.141-147; Kluwer Academic Publishers; New York (1999)

    PubMed=11994546; DOI=10.1093/molehr/8.5.485
    Blanchon L., Sauvant P., Bavik C., Gallot D., Charbonne F., Alexandre-Gouabau M.-C., Lemery D., Jacquetin B., Dastugue B., Ward S., Sapin V.
    Human choriocarcinoma cell line JEG-3 produces and secretes active retinoids from retinol.
    Mol. Hum. Reprod. 8:485-493(2002)

    PubMed=12966428; DOI=10.1038/sj.bjc.6601212
    Li K.K.C., Goodall J., Goding C.R., Liao S.-K., Wang C.-H., Lin Y.-C., Hiraga H., Nojima T., Nagashima K., Schaefer K.-L., Lee K.A.W.
    The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma.
    Br. J. Cancer 89:1072-1078(2003)

    PubMed=16797695; DOI=10.1016/j.placenta.2006.05.001
    Burleigh D.W., Kendziorski C.M., Choi Y.J., Grindle K.M., Grendell R.L., Magness R.R., Golos T.G.
    Microarray analysis of BeWo and JEG3 trophoblast cell lines: identification of differentially expressed transcripts.
    Placenta 28:383-389(2007)

    PubMed=20164919; DOI=10.1038/nature08768
    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=28161053; DOI=10.1016/j.placenta.2016.12.007
    Abou-Kheir W., Barrak J., Hadadeh O., Daoud G.
    HTR-8/SVneo cell line contains a mixed population of cells.
    Placenta 50:1-7(2017)

    PubMed=28724925; DOI=10.1038/s41598-017-06364-z
    Rothbauer M., Patel N., Gondola H., Siwetz M., Huppertz B., Ertl P.
    A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines.
    Sci. Rep. 7:5892-5892(2017)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=33096371; DOI=10.1016/j.placenta.2020.10.011
    Weber M., Weise A., Vasheghani F., Gohner C., Fitzgerald J.S., Liehr T., Markert U.R.
    Cytogenomics of six human trophoblastic cell lines.
    Placenta 103:72-75(2021)

    PubMed=33810901; DOI=10.1016/j.placenta.2021.02.022
    Pastuschek J., Nonn O., Gutierrez-Samudio R.N., Murrieta-Coxca J.M., Muller J., Sanft J., Huppertz B., Markert U.R., Groten T., Morales-Prieto D.M.
    Molecular characteristics of established trophoblast-derived cell lines.
    Placenta 108:122-133(2021)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0007017
    MCCL; MCC:0000257
    CLDB; cl2935
    CLDB; cl2936
    CCRID; 1101HUM-PUMC000071
    CCRID; 3101HUMTCHu195
    CCRID; 4201HUM-CCTCC00320
    Cell_Model_Passport; SIDM01218
    Cosmic-CLP; 907176
    DepMap; ACH-001530
    DSMZCellDive; ACC-463
    IGRhCellID; JEG3
    LINCS_LDP; LCL-1492
    TOKU-E; 2070
    Anatomy/cell type resourcesBTO; BTO:0002269
    Biological sample resourcesBioSample; SAMN01821538
    BioSample; SAMN01821638
    Cell line collections (Providers)AddexBio; C0030003/4940
    ATCC; HTB-36
    BCRC; 60428
    BCRJ; 0123
    CCTCC; GDC0320
    CLS; 300222
    DSMZ; ACC-463
    ECACC; 92120308
    IZSLER; BS TCL 181
    KCLB; 30036
    NCBI_Iran; C544
    Chemistry resourcesChEMBL-Cells; CHEMBL3308202
    ChEMBL-Targets; CHEMBL2366348
    GDSC; 907176
    PharmacoDB; JEG3_677_2019
    PubChem_Cell_line; CVCL_0363
    Encyclopedic resourcesWikidata; Q54898563
    Experimental variables resourcesEFO; EFO_0002066
    Gene expression databasesArrayExpress; E-MTAB-38
    ArrayExpress; E-MTAB-783
    ArrayExpress; E-MTAB-3610
    GEO; GSM48266
    GEO; GSM48267
    GEO; GSM48268
    GEO; GSM1669948
    Polymorphism and mutation databasesCosmic; 683654
    Cosmic; 907176
    Cosmic; 1312288
    Cosmic; 2077192
    IARC_TP53; 4344
    IARC_TP53; 21418
    Progenetix; CVCL_0363
    Proteomic databasesPRIDE; PXD030304
    Sequence databasesEGA; EGAS00001000978

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