HEC-1-A人子宫内膜腺癌细胞(STR鉴定正确)

    价 格💄🐭:¥1800

    期 货:现货(冻存管发2支)

    保藏中心🚇:BTCC

    资源编号:BTCC-1242

    产地:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameHEC-1-A
    SynonymsHec-1-A; HEC-1A; HEC1-A; HEC1A; Hec1A
    AccessionBTCC-1242
    Resource Identification InitiativeTo cite this cell line use: HEC-1-A (BTCC-1242)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: MD Anderson Cell Lines Project.
    Part of: PI3K genetic alteration cell panel (ATCC TCP-1028).
    Population: Japanese.
    Doubling time: 31 hours (DOI=10.1007/978-4-431-53981-0_1); 27 hours (PubMed=25984343).
    Microsatellite instability: Instable (MSI) (PubMed=12714694; PubMed=31068700).
    Omics: Array-based CGH.
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: Protein expression by reverse-phase protein arrays.
    Omics: shRNA library screening.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
    Sequence variations
    • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=12068308; DepMap).
    • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Heterozygous (DepMap).
    • Mutation; HGNC; 7329; MSH6; Simple; c.4001+1G>T; ClinVar=VCV001736936; Zygosity=Heterozygous; Note=Splice donor mutation (DepMap).
    • Mutation; HGNC; 9122; PMS2; Simple; p.Arg802Ter (c.2404C>T); ClinVar=VCV000009237; Zygosity=Heterozygous (DepMap).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (PubMed=15053063; PubMed=15901131; DepMap).
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0
    Native American1.14
    East Asian, North91.32
    East Asian, South6.71
    South Asian0.34
    European, North0.49
    European, South0
    DiseaseEndometrial adenocarcinoma (NCIt: C7359)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyParent: CVCL_1274 (HEC-1)
    Children:



    CVCL_AR90 (HEC-1-A-OZA1)CVCL_AR91 (HEC-1-A-OZA2)CVCL_AR92 (HEC-1-A-OZA3)
    CVCL_AR93 (HEC-1-A-OZA4)CVCL_AR94 (HEC-1-A-OZA5)CVCL_AR95 (HEC-1-A-OZA6)
    CVCL_0294 (HEC-1-B)

    Sex of cellFemale
    Age at sampling71Y
    CategoryCancer cell line
    STR profileSource(s): ATCC; Genomics_Center_BCF_Technion; IdentiCell; JCRB

    Markers:
    AmelogeninX
    CSF1PO10,12 (ATCC; Genomics_Center_BCF_Technion; IdentiCell)
    10,13,14 (JCRB)
    D1S165618.3,19
    D2S44111,13
    D2S133818,19
    D3S135815
    D5S81811,14,15 (ATCC)
    11,15 (Genomics_Center_BCF_Technion; IdentiCell; JCRB)
    D7S8209,11
    D8S117913,14
    D10S124812,14
    D12S39119
    D13S3179,11,14 (IdentiCell)
    11 (Genomics_Center_BCF_Technion; JCRB)
    11,12 (ATCC)
    D16S53912 (Genomics_Center_BCF_Technion; IdentiCell)
    12,13 (ATCC; JCRB)
    D18S5116,21
    D19S43313
    D21S1130,31
    D22S104511,15
    FGA21,22
    Penta D9,12
    Penta E11
    TH016,7
    TPOX8,9,11 (JCRB)
    8,11 (ATCC; Genomics_Center_BCF_Technion; IdentiCell)
    vWA18,19 (ATCC; Genomics_Center_BCF_Technion)
    18,19,20 (IdentiCell)
    19,20,22 (JCRB)

    Run an STR similarity search on this cell line
    Web pageshttp://www.identicell.eu/files/Sample-IdentiCell-report.pdf
    https://tcpaportal.org/mclp/
    Publications

    PubMed=4678779
    Kuramoto H.
    Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established line.
    Acta Obstet. Gynaecol. Jpn. 19:47-58(1972)

    PubMed=327080; DOI=10.1093/jnci/59.1.221
    Fogh J., Fogh J.M., Orfeo T.
    One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
    J. Natl. Cancer Inst. 59:221-226(1977)

    PubMed=833871; DOI=10.1093/jnci/58.2.209
    Fogh J., Wright W.C., Loveless J.D.
    Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
    J. Natl. Cancer Inst. 58:209-214(1977)

    PubMed=7459858
    Rousset M., Zweibaum A., Fogh J.
    Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
    Cancer Res. 41:1165-1170(1981)

    PubMed=3518877; DOI=10.3109/07357908609038260
    Fogh J.
    Human tumor lines for cancer research.
    Cancer Invest. 4:157-184(1986)

    PubMed=2436984; DOI=10.1016/0090-8258(87)90286-1
    Noumoff J., Haydock S.W., Sachdeva R., Heyner S., Pritchard M.L.
    Characteristics of cell lines derived from normal and malignant endometrial tissue.
    Gynecol. Oncol. 27:141-149(1987)

    PubMed=3410349; DOI=10.1016/0090-8258(88)90297-1
    Noumoff J.S., Simon D., Heyner S., Farber M., Haydock S.W., Pritchard M.L.
    Cytogenetics of an endometrial adenocarcinoma cell line and its implications.
    Gynecol. Oncol. 31:217-222(1988)

    PubMed=10381137; DOI=10.1016/s0304-3835(98)00270-5
    Ohta H., Sakamoto H., Satoh K.
    In vitro effects of gonadotropin-releasing hormone (GnRH) analogue on cancer cell sensitivity to cis-platinum.
    Cancer Lett. 134:111-118(1998)

    PubMed=12068308; DOI=10.1038/nature00766
    Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
    Mutations of the BRAF gene in human cancer.
    Nature 417:949-954(2002)

    PubMed=12227503; DOI=10.1111/j.1749-0774.2002.tb00103.x
    Kurarmoto H., Hamano M., Imai M.
    HEC-1 cells.
    Hum. Cell 15:81-95(2002)

    DOI=10.1007/978-4-431-53981-0_1
    Kuramoto H., Hamano M., Imai M., Fujisawa T., Kamata Y., Arai T., Kawaguchi M.
    HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
    (In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo (2003)

    PubMed=12714694; DOI=10.1093/mutage/18.3.277
    Yamada N.A., Castro A., Farber R.A.
    Variation in the extent of microsatellite instability in human cell lines with defects in different mismatch repair genes.
    Mutagenesis 18:277-282(2003)

    PubMed=12893190; DOI=10.1016/s0090-8258(03)00335-4
    Tanaka R., Saito T., Ashihara K., Nishimura M., Mizumoto H., Kudo R.
    Three-dimensional coculture of endometrial cancer cells and fibroblasts in human placenta derived collagen sponges and expression matrix metalloproteinases in these cells.
    Gynecol. Oncol. 90:297-304(2003)

    PubMed=15053063
    Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.
    Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.
    Eur. J. Gynaecol. Oncol. 25:55-60(2004)

    PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
    Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
    Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
    Pathol. Res. Pract. 201:109-115(2005)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=20218740; DOI=10.1177/153303461000900207
    Wang Y.-M., Yang D., Cogdell D., Hu L.-M., Xue F.-X., Broaddus R., Zhang W.
    Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.
    Technol. Cancer Res. Treat. 9:179-189(2010)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
    Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
    DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
    Gynecol. Oncol. 127:241-248(2012)

    PubMed=25984343; DOI=10.1038/sdata.2014.35
    Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
    Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
    Sci. Data 1:140035-140035(2014)

    PubMed=25485619; DOI=10.1038/nbt.3080
    Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
    A comprehensive transcriptional portrait of human cancer cell lines.
    Nat. Biotechnol. 33:306-312(2015)

    PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
    Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
    Characterization of human cancer cell lines by reverse-phase protein arrays.
    Cancer Cell 31:225-239(2017)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
    Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
    Quantitative proteomics of the Cancer Cell Line Encyclopedia.
    Cell 180:387-402.e16(2020)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0003674
    MCCL; MCC:0000183
    CCRID; 3101HUMTCHu149
    Cell_Model_Passport; SIDM00595
    DepMap; ACH-000954
    IGRhCellID; HEC1A
    Anatomy/cell type resourcesBTO; BTO:0002960
    Biological sample resourcesBioSample; SAMN03471093
    BioSample; SAMN03472456
    BioSample; SAMN10988293
    Cell line collections (Providers)ATCC; HTB-112
    BCRC; 60552
    CLS; 305077
    JCRB; JCRB1117
    JCRB; NIHS0388 - Discontinued
    Chemistry resourcesChEMBL-Cells; CHEMBL4295424
    ChEMBL-Targets; CHEMBL4296424
    PharmacoDB; HEC1A_524_2019
    PubChem_Cell_line; CVCL_0293
    Encyclopedic resourcesWikidata; Q54882246
    Experimental variables resourcesEFO; EFO_0002191

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