• Y79人视网膜母细胞瘤细胞(STR鉴定正确)

    价 格👩‍💻:¥2400

    期 货:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1247

    产地🧏🏿:中国

    套 餐☢️:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameY-79
    SynonymsY79; GM01232; GM01232E
    AccessionBTCC-1247
    Resource Identification InitiativeTo cite this cell line use: Y-79 (BTCC-1247)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Population: Caucasian.
    Doubling time: 52 hours (PubMed=4135597); 47 hours (PubMed=25326674); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~40 hours (DSMZ=ACC-246).
    Omics: Array-based CGH.
    Omics: Deep exome analysis.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Anecdotal: Named Y-79 because it was the result of the 79th attempt of a group at Yale to establish a retinoblastoma cell line.
    Derived from site: In situ; Eye, globe; UBERON=UBERON_0010230.
    Sequence variations
    • Mutation; HGNC; 9884; RB1; Unexplicit; Ex2-6del; Zygosity=Heterozygous (PubMed=3413073; PubMed=25326674).
    • Mutation; HGNC; 9884; RB1; Unexplicit; IVS20+1G>A; Zygosity=Heterozygous (PubMed=3413073; PubMed=25326674).
    HLA typingSource: CLS=300382
    Class I
    HLA-AA*02:01:01
    HLA-BB*40:01:02,51:01:01
    HLA-CC*03:04:01,12:03:01
    Class II
    HLA-DPDPB1*03:01,04:01
    HLA-DQDQA1*01:01:01,01:02:01

    DQB1*05:01:01,06:04:01
    HLA-DRDRB1*01:01:01,13:02:01
    DiseaseRetinoblastoma (NCIt: C7541)
    Retinoblastoma (ORDO: Orphanet_790)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:



    CVCL_S611 (RB355)CVCL_S610 (WERI-Rb-27)CVCL_B7IF (Y-79 CDDP-R)
    CVCL_B7IG (Y-79 Eto-R)CVCL_VA40 (Y79-6)CVCL_ZF06 (Y79-Luc)
    CVCL_A5SR (Y79/EDR)

    Sex of cellFemale
    Age at sampling2Y6M
    CategoryCancer cell line
    STR profileSource(s): AddexBio; ATCC; CLS; DepMap; DSMZ; ECACC; ICLC; JCRB; RCB

    Markers:
    AmelogeninX
    CSF1PO11,12
    D2S133820
    D3S135815,16
    D5S81811 (ICLC)
    11,12 (AddexBio; ATCC; CLS; DepMap; DSMZ; ECACC; JCRB; RCB)
    D7S8208,9
    D8S117913,16
    D13S31711,12
    D16S53913,14
    D18S5113,16
    D19S43313
    D21S1130,32
    FGA20,22 (DepMap; DSMZ)
    22 (CLS)
    Penta D12
    Penta E13,18
    TH016 (JCRB)
    6,9.3 (AddexBio; ATCC; CLS; DepMap; ECACC; ICLC; RCB)
    6,10 (DSMZ)
    TPOX8
    vWA15,18

    Run an STR similarity search on this cell line
    Publications

    PubMed=4135597; DOI=10.1093/jnci/53.2.347
    Reid T.W., Albert D.M., Rabson A.S., Russell P., Craft J.L., Chu E.W., Tralka T.S., Wilcox J.L.
    Characteristics of an established cell line of retinoblastoma.
    J. Natl. Cancer Inst. 53:347-360(1974)

    PubMed=679190
    McFall R.C., Nagy R.M., Nagle B.T., McGreevy L.M.
    Scanning electron microscopic observation of two retinoblastoma cell lines.
    Cancer Res. 38:2827-2835(1978)

    PubMed=6167750; DOI=10.1093/jnci/67.2.301
    Gilbert F., Balaban G.B., Breg W.R., Gallie B.L., Reid T., Nichols W.W.
    Homogeneously staining region in a retinoblastoma cell line: relevance to tumor initiation and progression.
    J. Natl. Cancer Inst. 67:301-306(1981)

    PubMed=6351622; DOI=10.1016/S0002-9394(14)77822-5
    Ohashi Y., Sasabe T., Nishida T., Nishi Y., Higashi H.
    Hanganutziu-Deicher heterophile antigen in human retinoblastoma cells.
    Am. J. Ophthalmol. 96:321-325(1983)

    DOI=10.5795/jjscc.24.451
    Tsumuraya M., Nakajima T., Terasaki T., Kodama T., Shimosato Y., Higuchi H., Uei Y.
    Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
    Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985)

    PubMed=3518877; DOI=10.3109/07357908609038260
    Fogh J.
    Human tumor lines for cancer research.
    Cancer Invest. 4:157-184(1986)

    PubMed=3413073; DOI=10.1073/pnas.85.16.6017
    Lee E.Y.-H.P., Bookstein R., Young L.-J., Lin C.-J., Rosenfeld M.G., Lee W.-H.
    Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79.
    Proc. Natl. Acad. Sci. U.S.A. 85:6017-6021(1988)

    PubMed=2917337; DOI=10.1016/0165-4608(89)90079-4
    Horsthemke B., Greger V., Becher R., Passarge E.
    Mechanism of i(6p) formation in retinoblastoma tumor cells.
    Cancer Genet. Cytogenet. 37:95-102(1989)

    PubMed=1679230; DOI=10.3109/13816819109023085
    Madreperla S.A., Bookstein R., Jones O.W., Lee W.-H.
    Retinoblastoma cell lines Y79, RB355 and WERI-Rb27 are genetically related.
    Ophthalmic Paediatr. Genet. 12:49-56(1991)

    CLPUB00447
    Mulivor R.A., Suchy S.F.
    1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
    (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992)

    PubMed=7689221; DOI=10.1073/pnas.90.16.7578
    Godbout R., Squire J.A.
    Amplification of a DEAD box protein gene in retinoblastoma cell lines.
    Proc. Natl. Acad. Sci. U.S.A. 90:7578-7582(1993)

    PubMed=7499444; DOI=10.1007/BF01213319
    Inomata M., Saijo N., Kawashima K., Kaneko A., Fujiwara Y., Kunikane H., Tanaka Y.
    Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid.
    J. Cancer Res. Clin. Oncol. 121:729-738(1995)

    PubMed=18036396; DOI=10.1016/j.cancergencyto.2007.08.014
    Paderova J., Orlic-Milacic M., Yoshimoto M., da Cunha Santos G., Gallie B.L., Squire J.A.
    Novel 6p rearrangements and recurrent translocation breakpoints in retinoblastoma cell lines identified by spectral karyotyping and mBAND analyses.
    Cancer Genet. Cytogenet. 179:102-111(2007)

    PubMed=18799932; DOI=10.1097/MPH.0b013e31816e232d
    Kim J.H., Kim J.H., Yu Y.S., Kim D.H., Kim Y.K., Kim K.-W.
    Comparative genomic hybridization analysis of newly established retinoblastoma cell lines of adherent growth compared with Y79 of nonadherent growth.
    J. Pediatr. Hematol. Oncol. 30:571-574(2008)

    PubMed=19686387; DOI=10.1111/j.1471-4159.2009.06322.x
    Glubrecht D.D., Kim J.-H., Russell L., Bamforth J.S., Godbout R.
    Differential CRX and OTX2 expression in human retina and retinoblastoma.
    J. Neurochem. 111:250-263(2009)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=21697133; DOI=10.1167/iovs.11-7479
    Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
    Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
    Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011)

    PubMed=23498719; DOI=10.1016/S1470-2045(13)70045-7
    Rushlow D.E., Mol B.M., Kennett J.Y., Yee S., Pajovic S., Theriault B.L., Prigoda-Lee N.L., Spencer C., Dimaras H., Corson T.W., Pang R., Massey C., Godbout R., Jiang Z., Zacksenhaus E., Paton K., Moll A.C., Houdayer C., Raizis A., Halliday W., Lam W.L., Boutros P.C., Lohmann D., Dorsman J.C., Gallie B.L.
    Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
    Lancet Oncol. 14:327-334(2013)

    PubMed=25326674; DOI=10.1007/s00418-014-1285-z
    Busch M., Philippeit C., Weise A., Dunker N.
    Re-characterization of established human retinoblastoma cell lines.
    Histochem. Cell Biol. 143:325-338(2015)

    PubMed=27050416; DOI=10.1371/journal.pone.0153011
    Ferrario A., Luna M., Rucker N., Wong S., Lederman A., Kim J., Gomer C.
    Targeting survivin enhances chemosensitivity in retinoblastoma cells and orthotopic tumors.
    PLoS ONE 11:E0153011-E0153011(2016)

    PubMed=27115612; DOI=10.1371/journal.pone.0153323
    Kooi I.E., Mol B.M., Massink M.P., de Jong M.C., de Graaf P., van der Valk P., Meijers-Heijboer H., Kaspers G.J.L., Moll A.C., te Riele H., Cloos J., Dorsman J.C.
    A meta-analysis of retinoblastoma copy numbers refines the list of possible driver genes involved in tumor progression.
    PLoS ONE 11:E0153323-E0153323(2016)

    DOI=10.3969/j.issn.1673-713X.2017.04.002
    Song W.-P., Zhang C.-Y., Zhang Y., Li Y., Cao R., Ye C., Zhang L., Shao R.-G., Li L., Zhao J.-Y.
    Generation of etoposide-resistant subline of human retinoblastoma Y79 cells and preliminary study of its resistance mechanism.
    Zhongguo Yiyao Sheng Wu Jishu 12:297-302(2017)

    PubMed=29162051; DOI=10.1186/s12885-017-3750-2
    Nair R.M., Balla M.M.S., Khan I., Kalathur R.K.R., Kondaiah P., Vemuganti G.K.
    In vitro characterization of CD133(lo) cancer stem cells in retinoblastoma Y79 cell line.
    BMC Cancer 17:779.1-779.12(2017)

    PubMed=29192327; DOI=10.3892/or.2017.6100
    Busch M.A., Papior D., Stephan H., Dunker N.
    Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines.
    Oncol. Rep. 39:160-172(2018)

    DOI=10.5005/jp-journals-10082-02230
    Kuduvalli S.S., Ramalakshmi O., Precilla S.D., Anitha T.S.
    Evaluation of cell doubling time in C6 and Y79 cell lines based on seeding density.
    SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019)

    PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018
    Schwermer M., Hiber M., Dreesmann S., Rieb A., Theissen J., Herold T., Schramm A., Temming P., Steenpass L.
    Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines.
    Exp. Cell Res. 375:92-99(2019)

    PubMed=32123578; DOI=10.1038/s41420-020-0237-8
    Aubry A., Yu T., Bremner R.
    Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy.
    Cell Death Discov. 6:2.1-2.12(2020)

    PubMed=32143590; DOI=10.1186/s12886-020-01348-6
    Song W.-P., Zheng S., Yao H.-J., Zhou X.-F., Li R., Zhang C.-Y., Zhao J.-Y., Wang L.-W., Shao R.-G., Li L.
    Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism.
    BMC Ophthalmol. 20:92.1-92.11(2020)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0009709
    CLO; CLO_0030277
    CLO; CLO_0051564
    CLDB; cl4796
    CLDB; cl4797
    CLDB; cl4798
    CLDB; cl4984
    Cell_Model_Passport; SIDM01395
    DepMap; ACH-001295
    DSMZCellDive; ACC-246
    IGRhCellID; Y79
    Anatomy/cell type resourcesBTO; BTO:0002920
    Biological sample resourcesBioSample; SAMN00803744
    BioSample; SAMN01821607
    BioSample; SAMN03472733
    BioSample; SAMN03473388
    Cell line collections (Providers)AddexBio; C0029001/4898
    ATCC; HTB-18
    BCRC; 60422
    BCRJ; 0380
    CLS; 300382
    Coriell; GM01232
    DSMZ; ACC-246
    ECACC; 86093003
    IBRC; C11182
    ICLC; HTL99029
    JCRB; JCRB3020
    JCRB; KURB2684 - Discontinued
    NCBI_Iran; C201
    RCB; RCB0427 - Discontinued
    RCB; RCB1645
    Chemistry resourcesChEMBL-Cells; CHEMBL3308054
    ChEMBL-Targets; CHEMBL613820
    PubChem_Cell_line; CVCL_1893
    Encyclopedic resourcesWikidata; Q54995129
    Experimental variables resourcesEFO; EFO_0002392

    更多>>相关产品

    总部地址🤞🏻:北京市怀柔区渤海镇怀沙路536号

    关注杏鑫
    在线咨询
    在线客服
    电话咨询
    微信客服
    返回顶部
    杏鑫娱乐专业提供👨🏼‍🎤:杏鑫娱乐😇🏋🏿‍♀️、杏鑫杏鑫平台等服务,提供最新官网平台、地址、注册、登陆、登录、入口、全站、网站、网页、网址、娱乐、手机版、app、下载、欧洲杯、欧冠、nba、世界杯、英超等,界面美观优质完美,安全稳定,服务一流,杏鑫娱乐欢迎您。