• CEM/C1人急性淋巴细胞白血病细胞(STR鉴定正确)

    价 格:¥1800

    期 货👩🏻‍💼:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1254

    产地:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameCEM/C1
    SynonymsCCRF-CEM C1; CEM-C1; CEM.C1; CEMC1
    AccessionBTCC-1254
    Resource Identification InitiativeTo cite this cell line use: CEM/C1 (BTCC-1254)
    CommentsPopulation: Caucasian.
    Selected for resistance to: ChEBI; CHEBI:27656; Camptothecin (CPT).
    Omics: SNP array analysis.
    Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
    Cell type: T-cell; CL=CL_0000084.
    Sequence variations
    • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
    • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=12068308).
    • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
    DiseaseChildhood T acute lymphoblastic leukemia (NCIt: C7953)
    Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyParent: CVCL_0207 (CCRF-CEM)
    Sex of cellFemale
    Age at sampling3Y11M
    CategoryCancer cell line
    STR profileSource(s): ATCC

    Markers:
    AmelogeninX
    CSF1PO11
    D5S81812,13
    D7S8209,12
    D13S3179,10,12
    D16S53910,13
    TH016,7
    TPOX8
    vWA18,19

    Run an STR similarity search on this cell line
    Publications

    PubMed=7579731
    Kapoor R., Slade D.L., Fujimori A., Pommier Y., Harker W.G.
    Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin.
    Oncol. Res. 7:83-95(1995)

    PubMed=8895760
    Geley S., Hartmann B.L., Hala M., Strasser-Wozak E.M.C., Kapelari K., Kofler R.
    Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.
    Cancer Res. 56:5033-5038(1996)

    PubMed=12068308; DOI=10.1038/nature00766
    Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
    Mutations of the BRAF gene in human cancer.
    Nature 417:949-954(2002)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0002355
    CCRID; 3101HUMTCHu212
    Cell_Model_Passport; SIDM01256
    IGRhCellID; CEMC1
    LINCS_LDP; LCL-1034
    Lonza; 241
    Anatomy/cell type resourcesBTO; BTO:0000225
    Biological sample resourcesBioSample; SAMN03471854
    Cell line collections (Providers)ATCC; CRL-2265
    CLS; 305103
    IZSLER; BS TCL 160
    Encyclopedic resourcesWikidata; Q54809269
    Experimental variables resourcesEFO; EFO_0001667
    Gene expression databasesArrayExpress; E-MTAB-38
    Polymorphism and mutation databasesCosmic; 724837
    Progenetix; CVCL_3496

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