KYSE-520人食管鳞癌细胞(STR鉴定正确)

    价 格:¥1800

    期 货:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1257

    产地🚨:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameKYSE-520
    SynonymsKYSE 520; KYSE520; Kyse520; KYSE0520
    AccessionBTCC-1257
    Resource Identification InitiativeTo cite this cell line use: KYSE-520 (BTCC-1257)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Population: Japanese.
    Doubling time: 30.2 hours (PubMed=1728357); ~30 hours (DSMZ=ACC-371).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
    Sequence variations
    • Mutation; HGNC; 11998; TP53; Simple; c.376-2A>T; ClinVar=VCV000458540; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=8575860).
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*24:20,24:20
    HLA-BB*54:01,54:01
    HLA-CC*01:02,01:02
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African1.52
    Native American1.16
    East Asian, North82.25
    East Asian, South12.37
    South Asian0
    European, North0
    European, South2.7
    DiseaseEsophageal squamous cell carcinoma (NCIt: C4024)
    Squamous cell carcinoma of the esophagus (ORDO: Orphanet_99977)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    Sex of cellFemale
    Age at sampling58Y
    CategoryCancer cell line
    STR profileSource(s): Cosmic-CLP; DSMZ; JCRB; PubMed=25877200

    Markers:
    AmelogeninX
    CSF1PO10
    D2S133819
    D3S135816
    D5S8189
    D7S82011
    D8S117914,16
    D13S31711
    D16S53910
    D18S5114
    D19S43314,16
    D21S1129
    FGA22
    Penta D12
    Penta E15
    TH019
    TPOX8
    vWA15,17

    Run an STR similarity search on this cell line
    Publications

    PubMed=1728357; DOI=10.1002/1097-0142(19920115)69:2<277::aid-cncr2820690202>3.0.CO;2-C
    Shimada Y., Imamura M., Wagata T., Yamaguchi N., Tobe T.
    Characterization of 21 newly established esophageal cancer cell lines.
    Cancer 69:277-284(1992)

    PubMed=7913084; DOI=10.1002/ijc.2910580224
    Kanda Y., Nishiyama Y., Shimada Y., Imamura M., Nomura H., Hiai H., Fukumoto M.
    Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.
    Int. J. Cancer 58:291-297(1994)

    PubMed=8575860; DOI=10.1002/(SICI)1097-0215(19960126)65:3<372::aid-ijc16>3.0.CO;2-C
    Tanaka H., Shibagaki I., Shimada Y., Wagata T., Imamura M., Ishizaki K.
    Characterization of p53 gene mutations in esophageal squamous cell carcinoma cell lines: increased frequency and different spectrum of mutations from primary tumors.
    Int. J. Cancer 65:372-376(1996)

    PubMed=9033652; DOI=10.1002/(SICI)1097-0215(19970207)70:4<437::aid-ijc11>3.0.CO;2-C
    Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.
    Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.
    Int. J. Cancer 70:437-442(1997)

    PubMed=11092977; DOI=10.1111/j.1349-7006.2000.tb00895.x
    Pimkhaokham A., Shimada Y., Fukuda Y., Kurihara N., Imoto I., Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.
    Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.
    Jpn. J. Cancer Res. 91:1126-1133(2000)

    PubMed=11520067; DOI=10.1006/bbrc.2001.5400
    Kan T., Shimada Y., Sato F., Maeda M., Kawabe A., Kaganoi J.-I., Itami A., Yamasaki S., Imamura M.
    Gene expression profiling in human esophageal cancers using cDNA microarray.
    Biochem. Biophys. Res. Commun. 286:792-801(2001)

    PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
    Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E., Sidransky D.
    PUMA in head and neck cancer.
    Cancer Lett. 199:75-81(2003)

    PubMed=15172977; DOI=10.1158/0008-5472.CAN-04-0172
    Sonoda I., Imoto I., Inoue J., Shibata T., Shimada Y., Chin K., Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.
    Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
    Cancer Res. 64:3741-3747(2004)

    PubMed=16045545; DOI=10.1111/j.0959-9673.2005.00431.x
    Ban S., Michikawa Y., Ishikawa K.-I., Sagara M., Watanabe K., Shimada Y., Inazawa J., Imai T.
    Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.
    Int. J. Exp. Pathol. 86:231-240(2005)

    PubMed=20164919; DOI=10.1038/nature08768
    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=25485619; DOI=10.1038/nbt.3080
    Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
    A comprehensive transcriptional portrait of human cancer cell lines.
    Nat. Biotechnol. 33:306-312(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=30629668; DOI=10.1371/journal.pone.0210404
    Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
    Screening human cell lines for viral infections applying RNA-Seq data analysis.
    PLoS ONE 14:E0210404-E0210404(2019)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0007136
    Cell_Model_Passport; SIDM01025
    CGH-DB; 289-1
    CGH-DB; 9238-4
    Cosmic-CLP; 753575
    DepMap; ACH-000637
    DSMZCellDive; ACC-371
    LINCS_LDP; LCL-1556
    Biological sample resourcesBioSample; SAMN03471053
    BioSample; SAMN10987932
    Cell line collections (Providers)DSMZ; ACC-371
    JCRB; JCRB1439
    Chemistry resourcesChEMBL-Cells; CHEMBL3307804
    ChEMBL-Targets; CHEMBL612701
    GDSC; 753575
    PharmacoDB; KYSE520_811_2019
    PubChem_Cell_line; CVCL_1355
    Encyclopedic resourcesWikidata; Q54900834
    Experimental variables resourcesEFO; EFO_0006632

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