• TOV-112D人上皮性卵巢癌细胞(STR鉴定正确)

    价 格👨🏽‍🦲:¥3000

    期 货:现货(冻存管发2支)

    保藏中心👨🏼‍💼📅:BTCC

    资源编号:BTCC-1280

    产地🤶🏽:中国

    套 餐🔊:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameTOV-112D
    SynonymsTOV-112d; TOV112D; TOV-112; TOV112
    AccessionBTCC-1280
    Resource Identification InitiativeTo cite this cell line use: TOV-112D (BTCC-1280)
    CommentsGroup: Patented cell line.
    Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: KuDOS 95 cell line panel.
    Part of: MD Anderson Cell Lines Project.
    Part of: OCCP ovarian cancer cell line panel.
    Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11371.
    Doubling time: 0.8 day (PubMed=10949993); 1.0 +- 0.2 days (PubMed=18507860); 22 hours (PubMed=25984343); 1.49 days (PubMed=22931248); 29.13 hours (GrayJW panel).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Array-based CGH.
    Omics: Deep exome analysis.
    Omics: Deep proteome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: Genome sequenced.
    Omics: Protein expression by reverse-phase protein arrays.
    Omics: shRNA library screening.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
    Sequence variations
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*03:01,03:01
    HLA-BB*14:01,14:01
    HLA-CC*08:02,08:02
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0
    Native American0.33
    East Asian, North2.98
    East Asian, South0
    South Asian0.16
    European, North53.45
    European, South43.09
    DiseaseOvarian endometrioid adenocarcinoma (NCIt: C7979)
    Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:

    CVCL_IQ56 (TOV-112DR)
    Sex of cellFemale
    Age at sampling42Y
    CategoryCancer cell line
    STR profileSource(s): ATCC; Cosmic-CLP; Direct_author_submission; PubMed=22710073; PubMed=25230021; PubMed=25877200; PubMed=30485824

    Markers:
    AmelogeninX
    CSF1PO12
    D2S133819,24
    D3S135815
    D5S81810
    D7S8209,10
    D8S11799,13
    D13S3178
    D16S5399,12 (ATCC; Cosmic-CLP; Direct_author_submission; PubMed=22710073; PubMed=25877200; PubMed=30485824)
    11,12 (PubMed=25230021)
    D18S5117
    D19S43314
    D21S1131
    FGA20
    Penta D9
    Penta E11
    TH016
    TPOX8,11
    vWA18

    Run an STR similarity search on this cell line
    Web pageshttps://tcpaportal.org/mclp/
    Publications

    Patent=US5710038
    Mes-Masson A.-M., Provencher D.M.
    Primary cultures of normal and tumoral human ovarian epithelium.
    Patent number US5710038, 20-Jan-1998

    PubMed=10949993; DOI=10.1290/1071-2690(2000)036<0357:cofneo>2.0.CO;2
    Provencher D.M., Lounis H., Champoux L., Tetrault M., Manderson E.N., Wang J.C., Eydoux P., Savoie R., Tonin P.N., Mes-Masson A.-M.
    Characterization of four novel epithelial ovarian cancer cell lines.
    In Vitro Cell. Dev. Biol. Anim. 36:357-361(2000)

    PubMed=11641787; DOI=10.1038/sj.onc.1204804
    Tonin P.N., Hudson T.J., Rodier F., Bossolasco M., Lee P.D., Novak J., Manderson E.N., Provencher D.M., Mes-Masson A.-M.
    Microarray analysis of gene expression mirrors the biology of an ovarian cancer model.
    Oncogene 20:6617-6626(2001)

    PubMed=16380993; DOI=10.1002/ijc.21671
    Huang K.-C., Park D.C., Ng S.-K., Lee J.Y., Ni X., Ng W.-C., Bandera C.A., Welch W.R., Berkowitz R.S., Mok S.C., Ng S.-W.
    Selenium binding protein 1 in ovarian cancer.
    Int. J. Cancer 118:2433-2440(2006)

    PubMed=18507860; DOI=10.1186/1471-2407-8-152
    Ouellet V., Zietarska M., Portelance L., Lafontaine J., Madore J., Puiffe M.-L., Arcand S.L., Shen Z., Hebert J., Tonin P.N., Provencher D.M., Mes-Masson A.-M.
    Characterization of three new serous epithelial ovarian cancer cell lines.
    BMC Cancer 8:152.1-152.18(2008)

    PubMed=19058220; DOI=10.1002/ijc.24058
    Dafou D., Ramus S.J., Choi K., Grun B., Trott D.A., Newbold R.F., Jacobs I.J., Jones C., Gayther S.A.
    Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells.
    Int. J. Cancer 124:1037-1044(2009)

    PubMed=19288585; DOI=10.1002/elps.200800505
    Dai L., Li C., Shedden K.A., Misek D.E., Lubman D.M.
    Comparative proteomic study of two closely related ovarian endometrioid adenocarcinoma cell lines using cIEF fractionation and pathway analysis.
    Electrophoresis 30:1119-1131(2009)

    PubMed=20204287; DOI=10.3892/or_00000728
    Langland G.T., Yannone S.M., Langland R.A., Nakao A., Guan Y.-H., Long S.B.T., Vonguyen L., Chen D.J., Gray J.W., Chen F.-Q.
    Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
    Oncol. Rep. 23:1021-1026(2010)

    PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170
    Hanrahan A.J., Schultz N., Westfal M.L., Sakr R.A., Giri D.D., Scarperi S., Janakiraman M., Olvera N., Stevens E.V., She Q.-B., Aghajanian C., King T.A., de Stanchina E., Spriggs D.R., Heguy A., Taylor B.S., Sander C., Rosen N., Levine D.A., Solit D.B.
    Genomic complexity and AKT dependence in serous ovarian cancer.
    Cancer Discov. 2:56-67(2012)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
    Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
    DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
    Gynecol. Oncol. 127:241-248(2012)

    PubMed=22931248; DOI=10.1186/1471-2407-12-379
    Letourneau I.J., Quinn M.C.J., Wang L.-L., Portelance L., Caceres K.Y., Cyr L., Delvoye N., Meunier L., de Ladurantaye M., Shen Z., Arcand S.L., Tonin P.N., Provencher D.M., Mes-Masson A.-M.
    Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer.
    BMC Cancer 12:379.1-379.16(2012)

    PubMed=24023729; DOI=10.1371/journal.pone.0072162
    Anglesio M.S., Wiegand K.C., Melnyk N., Chow C., Salamanca C.M., Prentice L.M., Senz J., Yang W., Spillman M.A., Cochrane D.R., Shumansky K., Shah S.P., Kalloger S.E., Huntsman D.G.
    Type-specific cell line models for type-specific ovarian cancer research.
    PLoS ONE 8:E72162-E72162(2013)

    PubMed=25230021; DOI=10.1371/journal.pone.0103988
    Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
    Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
    PLoS ONE 9:E103988-E103988(2014)

    PubMed=25984343; DOI=10.1038/sdata.2014.35
    Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
    Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
    Sci. Data 1:140035-140035(2014)

    PubMed=25485619; DOI=10.1038/nbt.3080
    Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
    A comprehensive transcriptional portrait of human cancer cell lines.
    Nat. Biotechnol. 33:306-312(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=27235858; DOI=10.1016/j.ygyno.2016.05.028
    Hernandez L., Kim M.K., Lyle L.T., Bunch K.P., House C.D., Ning F., Noonan A.M., Annunziata C.M.
    Characterization of ovarian cancer cell lines as in vivo models for preclinical studies.
    Gynecol. Oncol. 142:332-340(2016)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=27561551; DOI=10.1038/ncomms12645
    Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.Y., Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.
    Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
    Nat. Commun. 7:12645.1-12645.14(2016)

    PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
    Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
    Characterization of human cancer cell lines by reverse-phase protein arrays.
    Cancer Cell 31:225-239(2017)

    PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096
    Papp E., Hallberg D., Konecny G.E., Bruhm D.C., Adleff V., Noe M., Kagiampakis I., Palsgrove D., Conklin D., Kinose Y., White J.R., Press M.F., Drapkin R.I., Easwaran H., Baylin S.B., Slamon D.J., Velculescu V.E., Scharpf R.B.
    Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
    Cell Rep. 25:2617-2633(2018)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=33328126; DOI=10.1016/j.ygyno.2020.12.004
    Karnezis A.N., Chen S.Y.-T., Chow C., Yang W., Hendricks W.P.D., Ramos P., Briones N., Mes-Masson A.-M., Bosse T., Gilks C.B., Trent J.M., Weissman B.E., Huntsman D.G., Wang Y.-M.
    Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.
    Gynecol. Oncol. 160:568-578(2021)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0009384
    Cell_Model_Passport; SIDM01170
    Cosmic-CLP; 1299070
    DepMap; ACH-000048
    LINCS_LDP; LCL-1920
    Anatomy/cell type resourcesBTO; BTO:0005182
    Biological sample resourcesBioSample; SAMN03471348
    BioSample; SAMN10988342
    Cell line collections (Providers)ATCC; CRL-11731
    BCRC; 60408
    Chemistry resourcesChEMBL-Cells; CHEMBL3707165
    ChEMBL-Targets; CHEMBL3707166
    GDSC; 1299070
    PharmacoDB; TOV112D_1604_2019
    PubChem_Cell_line; CVCL_3612
    Encyclopedic resourcesWikidata; Q54972795
    Experimental variables resourcesEFO; EFO_0005263

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