• RGC-5小鼠视网膜神经节细胞

    价 格：¥1800

    期 货：现货（冻存管发2支）

    保藏中心：BTCC

    资源编号：BTCC-2045

    产地：中国

    套 餐：

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告（COA）

    Cell line nameRGC-5
    SynonymsRGC5
    AccessionBTCC-2045
    Resource Identification InitiativeTo cite this cell line use: RGC-5 (BTCC-2045)
    CommentsGroup: Patented cell line.
    Problematic cell line: Misidentified. Originally thought to be of rat origin but found to be from mouse (PubMed=19443730; PubMed=24664692). Is probably identical to 661W (PubMed=23975727; PubMed=24021353). But the originator of the 661W cell is partially contesting this claim (PubMed=24472671).
    Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00472.
    Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6600.
    Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
    Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
    Cell type: Retinal cone cell; CL=CL_0000573.
    Species of originMus musculus (Mouse) (NCBI Taxonomy: 10090)
    Breed/subspecies: C57BL/6N transgenic.
    HierarchyParent: CVCL_6240 (661W)
    Sex of cellMale
    CategoryTransformed cell line
    Web pageshttp://cellbiology.med.unsw.edu.au/units/lab/cells/cell_RGC5.htm
    https://iclac.org/education/rgc-5/
    https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
    Publications

    PubMed=11165366; DOI=10.1016/S0169-328X(00)00224-2
    Krishnamoorthy R.R., Agarwal P., Prasanna G., Vopat K., Lambert W., Sheedlo H.J., Pang I.-H., Shade D.L., Wordinger R.J., Yorio T., Clark A.F., Agarwal N.
    Characterization of a transformed rat retinal ganglion cell line.
    Brain Res. Mol. Brain Res. 86:1-12(2001)

    Patent=US7303915
    Levin L.A.
    In vitro-differentiated retinal ganglion cells and method for producing same.
    Patent number US7303915, 04-Dec-2007

    PubMed=19443730; DOI=10.1167/iovs.09-3484
    Van Bergen N.J., Wood J.P., Chidlow G., Trounce I.A., Casson R.J., Ju W.K., Weinreb R.N., Crowston J.G.
    Recharacterization of the RGC-5 retinal ganglion cell line.
    Invest. Ophthalmol. Vis. Sci. 50:4267-4272(2009)

    PubMed=23975727; DOI=10.1167/iovs.13-12085
    Krishnamoorthy R.R., Clark A.F., Daudt D., Vishwanatha J.K., Yorio T.
    A forensic path to RGC-5 cell line identification: lessons learned.
    Invest. Ophthalmol. Vis. Sci. 54:5712-5719(2013)

    PubMed=24021353; DOI=10.1016/j.exer.2013.08.002
    Clark A.F., Tamm E.R., Al-Ubaidi M.R., Hollyfield J.G.
    On the use of immortalized ocular cell lines in vision research: the unfortunate story of RGC-5.
    Exp. Eye Res. 116:433-433(2013)

    PubMed=24472671; DOI=10.1016/j.exer.2013.10.012
    Al-Ubaidi M.R.
    RGC-5: are they really 661W? The saga continues.
    Exp. Eye Res. 119:115-115(2014)

    PubMed=24664692; DOI=10.1007/978-1-4614-3209-8_19
    Sippl C., Tamm E.R.
    What is the nature of the RGC-5 cell line?
    Adv. Exp. Med. Biol. 801:145-154(2014)

    PubMed=29203899; DOI=10.1038/s41598-017-17241-0
    Sayyad Z., Sirohi K., Radha V., Swarup G.
    661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.
    Sci. Rep. 7:16855-16855(2017)

    Cross-references
    Cell line databases/resourcesTOKU-E; 3594
    Anatomy/cell type resourcesBTO; BTO:0005118
    Biological sample resourcesBioSample; SAMN03151607
    Encyclopedic resourcesWikidata; Q54950255

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